Accumbal D1R Neurons Projecting to Lateral Hypothalamus Authorize Feeding
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چکیده
منابع مشابه
Accumbal D1R Neurons Projecting to Lateral Hypothalamus Authorize Feeding
Feeding satisfies metabolic need but is also controlled by external stimuli, like palatability or predator threat. Nucleus accumbens shell (NAcSh) projections to the lateral hypothalamus (LH) are implicated in mediating such feeding control, but the neurons involved and their mechanism of action remain elusive. We show that dopamine D1R-expressing NAcSh neurons (D1R-MSNs) provide the dominant s...
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The growing prevalence of overeating disorders is a key contributor to the worldwide obesity epidemic. Dysfunction of particular neural circuits may trigger deviations from adaptive feeding behaviors. The lateral hypothalamus (LH) is a crucial neural substrate for motivated behavior, including feeding, but the precise functional neurocircuitry that controls LH neuronal activity to engage feedin...
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ژورنال
عنوان ژورنال: Neuron
سال: 2015
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2015.09.038